Ovarian Rejuvenation


The World’s First and Only Fertility Center offering Generation 4 Ovarian Rejuvination Therapy


Gen 5 Fertility (G5F) was the first and is still the only IVF clinic in the United States (and, of course, the only one in San Diego) to focus on therapeutic and research applications for Platelet Rich Plasma (PRP), Enriched Platelet Factors (EPF) including EnPLAF, ULTRA, and the ULTIMATE, all human Ovarian Rejuvenation procedures.

And Gen 5 Fertility Center is directed by Dr. Samuel Wood, one of the leading fertility specialists in the world. He has helped patients from all continents have the baby they desire. Dr. Wood is a board-certified Reproductive Endocrinologist and world-renowned Fertility Specialist as well as an expert in Reproductive Genetics with over 25 years of clinical experience.

Hundreds of patients have done Ovarian Rejuvenation with Gen 5 Fertility Center physicians. Generation 3 was developed using advanced new techniques and it works for a variable percentage of women with diminished ovarian reserve depending on their individual characteristics. We have published multiple research papers based on clinical studies giving details of the Ovarian Rejuvenation procedure and its effects. It is a near-painless procedure for virtually all women and so it almost never requires any anesthesia. It is a safe and affordable technique that gives women who have suffered for so long a chance for success. Generation 4 Ovarian Rejuvenation is our latest treatment strategy and is specifically designed for women who are reproductively older, those with very low levels of AMH, and those with no or very low Antral Follicle Count (AFC). Although most of our work focuses on aging and rejuvenation and our work to improve success rates, other study designs stress other benefits of attempting to restore ovarian function. Soon, much more information about this groundbreaking technique will be available.

We offer this as an enhancement of the original PRP protocol pioneered in Greece. It is a quite safe and relatively new procedure in which platelets, platelet-derived growth factors or both are placed inside the ovaries in the areas that typically contain eggs. This is achieved by a near-painless injection through the top of the vagina under direct ultrasound guidance. Only very rarely is anesthesia required.

If the ovarian response is improved, then In addition to other ways these techniques might be helpful, Ovarian Rejuvenation may ovarian function by stimulating ovarian stem cells so that they develop into eggs. If the number and/or quality of the oocytes (eggs) available for IVF is improved, the chance of pregnancy may also be improved and the need for donor eggs is reduced.

Members of our team worked on the first registered “Ovarian Rejuvenation” human research study in the United States, as listed with ClinicalTrials.gov.

To date, our group has safely completed hundreds of ovarian PRP injections using established methodologies, including some with precision laboratory support from speciality laboratories.

Because ovarian PRP and Enriched Platelet Factor infusions involve the use of a patient’s own platelets, rather than donor platelets, there is no risk of cell rejection or graft-versus-host reaction. The procedure is almost always well tolerated and there have been no adverse events or complications associated with either of these procedures as performed using our proprietary method, one used by no other fertility specialist in the world.

Below we answer many of the questions we have received about this revolutionary technology from patients throughout the world.

We know it can be hard.

If you are really frustrated to become pregnant and feel it may be impossible because you have been told:
you are “too old”
your AMH is “too low”
your FSH is “too high” or your eggs are “low or poor quality”
you “don’t make enough” of them
that all of “your embryos are abnormal,”

We may have the perfect solution for you, one you won’t be able to find elsewhere in the world. Ovarian Rejuvenation Generations 1 through 4!

Ovarian Rejuvenation FAQs