Research

One of the most important areas of research in reproductive medicine today is the use of PRP or EPF for Ovarian Rejuvenation. PRP is short for Platelet Rich Plasma Therapy and ERF is the abbreviation for Enriched Platelet Factors ( including EnPLAF). These two therapies are similar but also have significant differences. Please see our detailed webpage about Ovarian Rejuvenation for more information.

Over the past few years, the clinical and research staff at Gen 5 Fertility has published several scientific papers about PRP / EnPLAF and other topics. Below are PDF versions of some of these. Additional papers have been accepted or are being considered for publication at the present time.

Click to see one of the most important of our recent publications, one that provides the logical thinking and some of the prior research that explains how platelet derived growth factors may serve to rejuvenate the ovaries. It’s not an easy read. But, because it provides many of the details behind these procedures, it may be worth the effort.

Sills ES (2022). Ovarian recovery via autologous platelet-rich plasma: New benchmarks for condensed cytokine applications to reverse reproductive aging. Aging Medicine. 2022;00:1–5. DOI:
http://dx.doi.org/10.1002/agm2.1216

Sills ES, Wood SH (2021). Appraisal of Experimental Methods to Manage Menopause and Infertility: Intraovarian Platelet-Rich Plasma vs. Condensed Platelet-Derived Cytokines. Medicina 58(1): 3 10.3390/medicina58010003

Sills ES, Rickers NS, Wood SH. (2020) Intraovarian insertion of autologous platelet growth factors as cell-free concentrate: Fertility recovery and first unassisted conception with term delivery at age over 40. Int J Reprod BioMed 2020;18(12):1081-1086.
https://knepublishing.com/index.php/ijrm/article/download/8030/13806

Sills ES, Wood SH. (2020). An experimental model for peri-conceptual COVID-19 pregnancy loss and proposed interventions to optimize outcomes. Int J Mol Cell Med 2020;9(3):1-8.
http://dx.doi.org/10.22088/IJMCM.BUMS.9.3.180

Wood SH, Sills, ES. (2020). Intraovarian vascular enhancement via stromal injection of platelet-derived growth factors: Exploring subsequent oocyte chromosomal status and in vitro fertilization outcomes. Clinical and Experimental Reproductive Medicine 2020
https://doi.org/10.5653/cerm.2019.03405

Sills ES, Rickers NS, Peterson JL, Xiang Li, Wood SH. (2020) Regenerative Effect of Intraovarian Injection of Activated Autologous Platelet Rich Plasma: Serum anti-Mullerian Hormone Levels Measured Among Poor-Prognosis In Vitro Fertilization Patients. Intl J Regen Med 2020;47(2):94-100.

Sills, E. S., & Wood, S. H. (2019). Autologous Activated Platelet-Rich Plasma Injection into Adult Human Ovary Tissue: Molecular Mechanism, Analysis, and Discussion of Reproductive Response. Bioscience reports, 39(6), BSR20190805.
https://doi.org/10.1042/BSR20190805

Sills, E. S., Li, X., Rickers, N. S., Wood, S. H., & Palermo, G. D. (2019). Metabolic and Neurobehavioral Response Rollowing Intraovarian Administration of Autologous Activated Platelet Rich Plasma: First Qualitative data. Neuro Endocrinology Letters, 39(6), 427–433.

Sills, E. S., Rickers, N. S., Li, X., & Palermo, G. D. (2018). First Data on In Vitro Fertilization and Blastocyst Formation After Intraovarian Injection of Calcium Gluconate-Activated Autologous Platelet Rich Plasma. Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology, 34(9), 756–760.
https://doi.org/10.1080/09513590.2018.1445219

Sills, E. S., Anderson, R. E., McCaffrey, M., Li, X., Arrach, N., & Wood, S. H. (2016). Gestational Surrogacy and the Role of Routine Embryo Screening: Current Challenges and Future Directions for Preimplantation Genetic Testing. Birth Defects Research. Part C, Embryo Today : reviews, 108(1), 98–102.
https://doi.org/10.1002/bdrc.21112

Sills ES, Harrity C, Wood SH, Tan SL. mTOR Inhibition via Low-Dose, Pulsed Rapamycin with Intraovarian Condensed Platelet Cytokines: An Individualized Protocol to Recover Diminished Reserve? J Pers Med 2023;13(7):1147. DOI: https://doi.org/10.3390/jpm13071147

Sills ES, Wood SH. Multichannel Recovery Potential with Activated Autologous Intraovarian Platelet-Rich Plasma and Its Derivatives. Medicines 10(7):40.

Sills ES, Wood SH. Discussion of field effects after intraovarian injection of autologous platelet-rich plasma. Bulletin of the National Research Centre 2023;47(1):52.

Sills ES, Wood SH, Walsh APH. Intraovarian condensed platelet cytokines for infertility and menopause—Mirage or miracle? Biochimie September 2022